教师简介

教师简介

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郑阿迪


教育背景:  

2010 — 2015 博士生,西安交通大学生命科学与技术学院

专业:生物化学与分子生物学

2006 — 2010 本科生,西安交通大学生命科学与技术学院

专业:生物工程

工作经历:  

2018 — 2020 博士后,瑞士洛桑大学,生物医学系

2015 — 2017 博士后,瑞典卡罗林斯卡91111威斯尼斯人app,生理与药理系

研究经历:  

1) 线粒体和氧化损伤在衰老相关疾病中的作用,并筛选有效自然化合物及其衍生物用于预防和治疗

相关课题: a. 姜黄素衍生物 B63 在结肠癌中的抗肿瘤作用研究

b. 羟基酪醇对大鼠子代认知功能的保护作用研究

c. 羟基酪醇对 db/db 糖尿病小鼠脑损伤的保护作用研究

2) 肿瘤迁移作用机制以及耐药性机制研究

相关课题: a. 去泛素蛋白酶在肿瘤迁移中的相关机制

b. 代谢相关基因在肺癌中的作用研究

c. 肝癌药物 sorafenib 的耐药机制研究

3) 高密度脂蛋白(HDL)的保护作用机制研究

相关课题: a. PI3K/AKT 是否介导 HDL 的保护作用

b. HDL 类海绵保护作用

c. HDL 调控新机制研究

参与的科研项目:  

1) 线粒体蛋白 C6ORF57 在代谢综合征中的作用研究,国家自然科学基金面上项目,批准号 31570777,骨干成

2) 羟基酪醇对孕期应激引起的子代认知功能障碍的预防和保护作用,国家自然科学基金青年项目,批准号

81201023,骨干成员

论文发表:  

1. Adi Zheng, Gilles Dubuis, Carla Susana Mendes Ferreira, Thomas Mercier, Laurent Decosterd and Christian Widmann.

HDLs extract lipophilic drugs from cells. J Cell Sci. (in revision; preprint in bioRxiv. DOI: 10.1101/2020.12.08.415984)

2. Adi Zheng, Hao Li, Zhihui Feng, and Jiankang Liu. Integrative systems analyses reveal Tstd1 as a potential HDL modulator  

in mice. Cells (accepted)

3. Adi Zheng, Christian Widmann. The interplay between serum amyloid A and HDLs. Curr Opin Lipidol. 2020  

Oct;31(5):300-301.

4. Adi Zheng*, Nadja Chevalier*, Margot Calderoni*, Gilles Dubuis, Olivier Dormond, Panos G Ziros, Gerasimos P Sykiotis,  

Christian Widmann. CRISPR/Cas9 Genome-Wide Screening Identifies KEAP1 as a Sorafenib, Lenvatinib, and Regorafenib  

Sensitivity Gene in Hepatocellular Carcinoma. Oncotarget. 2019 Dec 17;10(66):7058-7070. (* 为共同一作)

5. Adi Zheng, Gilles Dubuis, Carla Susana Mendes Ferreira, Jannick Pétremand, Güliz Vanli, Christian Widmann. The  

PI3K/Akt Pathway Is Not a Main Driver in HDL-mediated Cell Protection. Cell Signal. 2019 Oct;62:109347.  

6. Amanda Ouchida*, Merve Kacal*, Adi Zheng*, Gorbatchev Ambroise, Boxi Zhang, Erik Norberg. Helin Vakifahmetoglu

Norberg. USP10 regulates the stability of the EMT-transcription factor Slug/SNAI2. Biochem Biophys Res Commun. 2018  

Aug 25; 502(4):429-434. (* 为共同一作)

7. Boxi Zhang, Adi Zheng, Per Hydbring, Gorbatchev Ambroise, Amanda Tomie Ouchida, Michel Goiny, Helin  

Vakifahmetoglu-Norberg, and Erik Norberg. PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor  

Prognosis. Cell Rep. 2017 Jun 13;19(11):2289-2303.  

8. Lin Zhao, Hao Li, Yan Wang, Adi Zheng, Liu Cao, Jiankang Liu Autophagy Deficiency Leads to Impaired Antioxidant  

Defense via p62-FOXO1/3 Axis. Oxid Med Cell Longev. 2019 Dec 17;2019:2526314.  

9. Adi Zheng, Hao Li, Ke Cao, Jie Xu, Xuan Zou, Yuan Li, Cong Chen, Jiankang Liu, Zhihui Feng. Maternal hydroxytyrosol  

administration improves neurogenesis and cognitive function in prenatal stressed offspring. J Nutr Biochem. 2015  

Feb;26(2):190-9.  

10. Adi Zheng, Hao Li, Jie Xu, Ke Cao, Hua Li, Wenjun Pu, Ziqi Yang, Yunhua Peng, Jiangang Long, Jiankang Liu, and Zhihui  

Feng. Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: Role of AMPK  

activation. Brit J Nutr. 2015 Jun 14;113(11):1667-76.

11. Adi Zheng, Hao Li, Xun Wang, Zhihui Feng, Jie Xu, Ke Cao, Bo Zhou, Jing Wu and Jiankang Liu. Anticancer effect of a  

curcumin derivative B63: ROS production and mitochondrial dysfunction. Curr Cancer Drug Targets. 2014 Feb;14(2): 156-

166.

12. 郑阿迪, 刘健康, 冯智辉, 产前应激对子代的影响及潜在作用机制. 中国病理生理杂志, 2014 30 (3): 558-562

13. Ke Cao, Adi Zheng, Jie Xu, Hao Li, Jing Liu, Yunhua Peng, Jiangang Long, Xuan Zou, Yuan Li, Cong Chen, Jiankang Liu,  

Zhihui Feng. AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content  

and oxidative stress. Free Radic Biol Med. 2014 Oct;75:156-66.  

14. Xun Wang, Hao Li, Adi Zheng, Liang Yang, Jing Liu, Cong Chen, Ying Tang, Xuan Zou, Yuan Li, Jiangang Long, Jiankang  

Liu, Zhihui Feng. Mitochondrial dysfunction-associated OPA1 cleavage contributes to muscle degeneration: Preventative  

effect of hydroxytyrosol acetate. Cell Death Dis. 2014 Nov 13;5:e1521.  

15. Ke Cao, Jie Xu, Xuan Zou, Yuan Li, Cong Chen, Adi Zheng, Hao Li, Hua Li, Ignatius Man-Yau Szeto, Yujie Shi, Jiangang  

Long, Jiankang Liu and Zhihui Feng. Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates  

mitochondrial abnormalities in obese mice. Free Radic Biol Med. 2014 Feb;67:396-407.  

16. Xuan Zou, Chunhong Yan, Yujie Shi, Ke Cao, Jie Xu, Xun Wang, Cong Chen, Luo Cheng, Yuan Li, Hao Li, Adi Zheng,  

Wentao Pang, Jialong Zhao, Ignatius Man-Yau Szeto, Youyou Zhao, Zhizhong Dong, Junkuan Wang, Jiangang Long, Yong  

Zhang, Wuyuan Lu, Jiankang Liu, Zhihui Feng, Mitochondrial dysfunction in obesity associated nonalcoholic fatty liver  

disease: The protective effects of pomegranate with its active component punicalagin. Antioxid Redox Signal. 2014 Oct  

10;21(11):1557-70.